So, I have two excerpts from the Wikipedia article on Werewolves, both of which inspired different initial first thoughts about the game.
Many European countries and cultures influnced by them have stories of werewolves, including Albania (oik), France (loup-garou), Greece (lycanthropos), Spain, Mexico (hombre lobo), Bulgaria (valkolak), Turkey (kurtadam), Czech Republic/Slovakia (vlkodlak), Serbia/Montenegro/Bosnia (vukodlak, вукодлак), Russia (vourdalak, оборотень), Ukraine (vovkulak(a), vurdalak(a), vovkun, перевертень), Croatia (vukodlak), Poland (wilkołak), Romania (vârcolac, priculici), Macedonia (vrkolak), Scotland (werewolf, wulver), England (werewolf), Ireland (faoladh or conriocht), Germany (Werwolf), the Netherlands (weerwolf), Denmark/Sweden/Norway (Varulv), Norway/Iceland (kveld-ulf, varúlfur), Galicia (lobisón), Portugal/Brazil (lobisomem), Lithuania (vilkolakis and vilkatlakis), Latvia (vilkatis and vilkacis), Andorra (home llop), Hungary (Vérfarkas and Farkasember), Estonia (libahunt), Finland (ihmissusi and vironsusi), and Italy (lupo mannaro). In northern Europe, there are also tales about people changing into animals including bears, as well as wolves.
So, I read this long list of various lycanthropic traditions, and immediately thought… how awesome would it be to have a game purely about werewolves from various cultural traditions coming together and staging ULTIMATE COMBAT SHOWDOWNS! Now, the question is "But didn't White Wolf do that, with added angst?"
Yes, but… in my idea: Werewolves are a special form of covert cultural/national ambassador. When presidents/monarchs/dictators want to avoid full scale national conflict, they settle it by agreeing to a duel of the wolves. And so if Turkey and Italy were locked in political struggle and feared an impending war, they might agree to settle this matter by pitting their highest pedigree wolves against one another in raw, physical combat. Two men enter, one wolf leaves. The countries agree to let the outcome of the fight determine the outcome of international disputes.
The fights would involve psychological confrontation, struggling to control inner impulses, exchanges of wit and intrigue, and massive bloodshed. The characters would be built through a combat feat selection kind of process - something halfway between character creation in TSOY and lifepaths in BW. Not quite sure.
It'd be crunchy, and tactical, and there'd be some way to have the political events and countries stances towards each other influence the caged fight.
In Galician, Portuguese, and Brazilian folklore, it is the seventh of the sons (but sometimes the seventh child, a boy, after a line of six daughters) who becomes a werewolf (Lobisomem). In Portugal, the seventh daughter is supposed to become a witch and the seventh son a werewolf; the seventh son often gets the Christian name "Bento" (Portuguese form of "Benedict", meaning "blessed") as this is believed to prevent him from becoming a werewolf later in life. In Brazil, the seventh daughter become a headless (replaced with fire) horse called "Mula-sem-cabeça" (Headless Mule). The belief in the curse of the seventh son was so widespread in Northern Argentina (where the werewolf is called the lobizón), that seventh sons were frequently abandoned, ceded in adoption, or killed. A 1920 law decreed that the President of Argentina is the official godfather of every seventh son. Thus, the State gives a seventh son one gold medal in his baptism and a scholarship until his twenty first year. This effectively ended the abandonments, but there still persists a tradition in which the President godfathers seventh sons.
When your family abandoned you, you were far too young to comprehend it. Even now, you are still too young to comprehend it - they left you because of a number. The seventh son is always cursed in Argentinian myth.
But a man came to you. A compassionate, kind, strong man. He offered to take you in. He said he was to be trusted.
He made you a part of his secret service. You are no longer a scared, human child. You are a werewolf in the service of the President of Argentina.
Prepare to prove your worth and gratefulness.